hrp0094p2-431 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Combination therapy of hypogonadotropic hypogonadism with rFSH and hCG – case report

Kokoreva Kristina , Latyshev Oleg , Okminyan Goar , Kiseleva Elena , Samsonova Lyubov , Kasatkina Elvira , Brzhezinskaia Lyubov

Objective: assess advantages and disadvantages of the treatment of hypogonadotropic hypogonadism (HH) with rFSH and hCG.Materials: We report the case of а 16-year old patient with complaints of no development of secondary sexual characteristics. Patient was 174 cm (SDS growth 0.25 SD, SDS growth velocity 1.62 SD, SDS BMI -0.4 SD, target height correction 1.01 SD) with Tanner G1 P1 (penis length was 5 cm). Laboratory studies included LH < 0.1 m...

hrp0094p2-440 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Combination therapy of hypogonadotropic hypogonadism in boys with rFSH and hCG – case reports analyses

Kokoreva Kristina , Latyshev Oleg , Samsonova Lyubov , Kiseleva Elena , Okminyan Goar , Kasatkina Elvira , Brzhezinskaia Lyubov

Objective: to evaluate combination replacement therapy (CRT) with rFSH and hCG of hypogonadotropic hypogonadism (HH) in boys appropriateness and effectiveness.Materials: 1 boy with isolated HH (№1) and 2 boys (№2,3) with HH caused by hypopituitarism (HP) included. Antropometric data, Тanner; testosterone (T), LH, FSH, inhibin B, anti-Mullerian hormone (AMH), testicular volumes (TV), bone age (BA) evaluated in all patients. GnRH agonis...